mRNA potential health risks

K. Acevedo-Whitehouse, R. Bruno

Potential health risks of mRNA-based vaccine therapy: A hypothesis

Medical Hypotheses, Vol 171, 2023, 111015, ISSN 0306-9877

Available online: 25 January 2023

Science Direct

DOI: https://doi.org/10.1016/j.mehy.2023.111015

"In 2020, as a result of the COVID-19 pandemic, mRNA-based vaccines were developed at an unprecedented speed. In less than a year, two mRNA-based COVID-19 vaccines were designed, manufactured, tested and authorized for general and widespread use in the human population.

The safety profile of nucleoside-modified synthetic mRNA (hereafter, nms-mRNA) is far from completely understood. Trials to evaluate the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types, as well as potential interactions with the host genome were bypassed.

Regrettably, despite the lack of information, most scientific reviews that address risks and benefits of these vaccine platforms underscore their high levels of safety and claim that there is no risk of genomic integration with these vaccines."