Mumps outbreaks
- Vaccine Affect
- Sep 24, 2024
- 1 min read
Updated: Oct 7, 2024
Plotkin, Stanley A. MD.
We Need a New Mumps Vaccine
The Pediatric Infectious Disease Journal 43(4):p 350,
April 2024
EXCERPT
The reason for this is quite simple and has been known for years: namely that the Jeryl Lynn strain carries an HN protein of genotype A, whereas circulating mumps viruses carry a genetic component that is different, namely an HN protein belonging to genotype G. Inasmuch as the HN protein induces neutralizing antibodies, it is not surprising that a difference between that protein in the vaccine and in circulating mumps virus changes the vaccine’s ability to protect.
